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Efficacy of temozolomide (TMZ) monotherapy in patients with extrapulmonary poorly differentiated neuroendocrine carcinoma

Journal: Cancer Science

Article Title: Phase II study of temozolomide monotherapy in patients with extrapulmonary neuroendocrine carcinoma

doi: 10.1111/cas.14811

Figure Lengend Snippet: Efficacy of temozolomide (TMZ) monotherapy in patients with extrapulmonary poorly differentiated neuroendocrine carcinoma

Article Snippet: We reacted 4‐μm‐thick sections of representative blocks with mAbs against MGMT (MT 3.1; 1:25, GeneTex).

Techniques: Expressing

A, Serial section of a primary lesion of gastric neuroendocrine carcinoma with multiple liver metastases (case 3). Immunohistochemical findings revealed tumor cells were diffuse and moderately stained by O 6 ‐methylguanine DNA methyltransferase (MGMT) protein. This case was defined as intact. B, Serial section of a liver lesion of hepatic neuroendocrine carcinoma (case 9). Immunohistochemical findings revealed tumor cells were not stained by MGMT protein diffusely. This case was defined as deficient. C, Computed tomography findings revealed multiple liver metastases before treatment with temozolomide (case 9). D, Computed tomography findings revealed multiple liver metastases after two treatment cycles with temozolomide. Multiple liver tumors showed remarkable shrinkage (case 9)

Journal: Cancer Science

Article Title: Phase II study of temozolomide monotherapy in patients with extrapulmonary neuroendocrine carcinoma

doi: 10.1111/cas.14811

Figure Lengend Snippet: A, Serial section of a primary lesion of gastric neuroendocrine carcinoma with multiple liver metastases (case 3). Immunohistochemical findings revealed tumor cells were diffuse and moderately stained by O 6 ‐methylguanine DNA methyltransferase (MGMT) protein. This case was defined as intact. B, Serial section of a liver lesion of hepatic neuroendocrine carcinoma (case 9). Immunohistochemical findings revealed tumor cells were not stained by MGMT protein diffusely. This case was defined as deficient. C, Computed tomography findings revealed multiple liver metastases before treatment with temozolomide (case 9). D, Computed tomography findings revealed multiple liver metastases after two treatment cycles with temozolomide. Multiple liver tumors showed remarkable shrinkage (case 9)

Article Snippet: We reacted 4‐μm‐thick sections of representative blocks with mAbs against MGMT (MT 3.1; 1:25, GeneTex).

Techniques: Immunohistochemical staining, Staining, Computed Tomography